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Exploratory aims included observing changes in other PAL variables such as: total energy expenditure (EE) (daily living EE) and active EE (PA-induced EE) PA duration; lying down time; sleep duration and efficiency; and metabolic equivalent (MET) (intensity of PA) in all participants following neoadjuvant CRT and compare changes in the exercise group compared to the usual care control group.

This prospective pilot, non-randomised, parallel group, interventional controlled trial was a nested study of a clinical trial (West et al. This pilot study was approved by the North West Liverpool East Research and Ethics Committee (11/H1002/12) and registered with (NCT01325909).

NCT01325909430506.4Anaesthesia and Critical Care Research Area, NIHR Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, CE93, MP24, Tremona Road, Southampton, SO16 6YD UK 0000 0004 1936 9297grid.5491.9Integrative Physiology and Critical Illness Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, CE93, MP24, Tremona Road, Southampton, SO16 6YD UK 0000 0004 1936 8470grid.10025.36Department of Musculoskeletal Biology and MRC – Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA), Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

All participants underwent a continuous 72-h period of PA monitoring by Sense Wear biaxial accelerometer at baseline, immediately following neoadjuvant CRT (week 0), and at week 6 (following the exercise training programme).=0.010).